Clinical Pharmacology

The following activities are available for studies related to the pharmacokinetics and pharmacodynamics of cancer medicines.

• Prolonged Versus Standard Gemcitabine Infusion: Translation of Molecular Pharmacology to New Treatment Strategy
• The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer
• Glucarpidase (Carboxypeptidase G2) Intervention in Adult and Elderly Cancer Patients with Renal Dysfunction and Delayed Methotrexate Elimination After High-Dose Methotrexate Therapy
• Commentary: Oncologic Drugs in Patients with Organ Dysfunction: A Summary
• A Mechanistic Perspective of Monoclonal Antibodies in Cancer Therapy Beyond Target-Related Effects
• Flat-Fixed Dosing Versus Body Surface Area–Based Dosing of Anticancer Drugs in Adults: Does It Make a Difference?
• Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Sorafenib: A Review of Four Phase I Trials in Patients with Advanced Refractory Solid Tumors
• Chemotherapeutic Approaches for Targeting Cell Death Pathways EXPIRED
• The Emerging Role of Targeted Therapy for Hematologic Malignancies: Update on Bortezomib and Tipifarnib
• Concise Drug Reviews (4 activities)
• Clinical Pharmacology and Pharmacotherapy of Opioid Switching in Cancer Patients
• Tyrosine Kinase Inhibitors of Vascular Endothelial Growth Factor Receptors in Clinical Trials: Current Status and Future Directions
• Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction
• Complementary and Alternative Medicine During Cancer Treatment: Beyond Innocence
• Do Oncologists Believe New Cancer Drugs Offer Good Value? EXPIRED
• Current Knowledge and Future Directions of the Selective Epidermal Growth Factor Receptor Inhibitors Erlotinib (Tarceva®) and Gefitinib (Iressa®) EXPIRED
• Development of Farnesyl Transferase Inhibitors: A Review EXPIRED
• VEGF-Targeted Therapy: Therapeutic Potential and Recent Advances EXPIRED
• Cancer Pharmacogenomics: Powerful Tools in Cancer Chemotherapy and Drug Development EXPIRED
• Metastatic Carcinoid Tumors: A Clinical Review EXPIRED
• Practical Aspects of Weekly Docetaxel Administration Schedules EXPIRED
• Targeting VEGF in Cancer Treatment (6 activities)
• Microtubule Stabilization in the Treatment of Solid Tumors: Role of the Taxanes (4 activities)
• Penetrating Insights: Crossing the Cancer Cell Membrane to Improve Clinical Outcomes (4 activities)
• Clinical Trial Design for Target-Based Therapy EXPIRED
• ZD1839 (Iressa ™): A New Targeted Therapy for Solid Tumors (1 activity)
• Targeting Protein Kinase C: New Therapeutic Opportunities Against High-Grade Malignant Gliomas? EXPIRED
• STI571: Targeting BCR-ABL as Therapy for CML EXPIRED