Ixabepilone: A Novel Antineoplastic Agent with Low Susceptibility to Multiple Tumor Resistance Mechanisms
13-3-214_Vahdat
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CME Activity Information |
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Release Date: |
April 7, 2008 |
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Date Credit Expires: |
April 7, 2010 |
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Time to Complete: |
1 hour |
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Medium: |
Internet Online |
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*Click here
to learn more about our review process. |
Instructions for Participation
- Read the following information before beginning the educational activity
and click the "Take this course" link at the bottom of the page
- Study the educational activity
- Complete the CME quiz and evaluation
- After successful completion of the CME quiz and evaluation, you will receive
the credit or participation certificate
*The CME quiz and evaluation must be completed by April 7, 2010, in order
to receive the credit or participation certificate.
Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine
in breast cancer and are involved in providing patient care in a cancer care environment.
Learning Objectives
After completing this course, the reader should be able to:
- Evaluate the clinical significance of the lower susceptibility of epothilones
to key mechanisms of drug resistance.
- Explain the key mechanisms of drug resistance to which epothilones display
lower susceptibility.
- Describe the mechanism of action of ixabepilone.
- Describe how ixabepilone promotes tumor cell death through apoptosis.
- Identify six types of solid tumors in which ixabepilone has demonstrated
single-agent activity.
- Discuss the preclinical and clinical activity of ixabepilone in chemotherapy-resistant
tumors.
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This activity has been planned and implemented in accordance
with the Essential Areas and policies of the Accreditation Council for Continuing
Medical Education (ACCME) through the joint sponsorship of the School of Medicine
of The University of North Carolina at Chapel Hill and The Oncologist.
The School of Medicine of The University of North Carolina at Chapel Hill is accredited
by the ACCME to provide continuing medical education for physicians.
The School of Medicine of The University of North Carolina at Chapel Hill designates
this educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™.
Physicians should only claim credit commensurate with the extent of their participation
in the activity.
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Content Review
The content of this manuscript has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias.
Author Disclosure(s)
Linda Vahdat, M.D.
Credentials: Director, Weill Cornell Breast Center Research
Program, Weill Cornell Medical College, New York, New York, USA.
Disclosures: The author has received research funding for
ixabepilone from Bristol-Myers Squibb Oncology and for sunitinib from Pfizer.
Section Editors Disclosures
Gabriel N. Hortobagyi, M.D., F.A.C.P., and Kathleen I. Pritchard, M.D., have disclosed no financial relationships relevant to the content of this article.
CME Activity Director Disclosure
Frank M. Balis, M.D., CME Activity Director, has disclosed no financial relationships relevant to the content of this article.
Independent Peer Reviewers and Staff Managers Disclosures
No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers or staff managers.
Commercial Support
Non-governmental supporters of this activity: Abraxis BioScience,
AstraZeneca, Bristol-Myers Squibb Oncology, Merck, Pfizer, and sanofi-aventis
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