Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas
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CME Activity Information |
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Release Date: |
December 28, 2007 |
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Most Recent Review: |
December 28, 2007* |
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Most Recent Update: |
December 28, 2007 |
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Date Credit Expires: |
December 28, 2009 |
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Time to Complete: |
1 hour |
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Medium: |
Internet Online |
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*Click here
to learn more about our review process. |
Instructions for Participation
- Read the following information before beginning the educational activity
and click the "Take this course" link at the bottom of the page
- Study the educational activity
- Complete the CME quiz and evaluation
- After successful completion of the CME quiz and evaluation, you will receive
the credit or participation certificate
*The CME quiz and evaluation must be completed by December 28, 2009, in
order to receive the credit or participation certificate.
Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine
in the community oncology setting.
Learning Objectives
After completing this course, the reader should be able to:
- Describe the pathways involved in the natural resistance of cancer cells
to cytotoxic insults including radio-/chemotherapy.
- Explain autophagic cell death as a potent alternative tumor-suppressing
mechanism.
- Identify the common targets in apoptosis and autophagy resistance pathways
and the surrogate markers that could be used in clinical practice for proautophagic
therapy.
- Discuss the rationale for incorporating endoplasmic reticulum stress inhibitors
as adjuvant chemotherapies against apoptosis-resistant cancers.
Accreditation and Credit Designation
This activity has been planned and implemented in accordance
with the Essential Areas and policies of the Accreditation Council for Continuing
Medical Education (ACCME) through the joint sponsorship of the School of Medicine
of The University of North Carolina at Chapel Hill and The Oncologist.
The School of Medicine of The University of North Carolina at Chapel Hill is accredited
by the ACCME to provide continuing medical education for physicians.
The School
of Medicine of The University of North Carolina at Chapel Hill designates this
educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™.
Physicians should only claim credit commensurate with the extent of their participation
in the activity.
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of Medicine of The University of North Carolina at Chapel Hill to ensure balance,
independence, objectivity, and scientific rigor in all of its educational activities
and to include information free of commercial bias and based on the best evidence
available. All individuals in a position to influence the content of this activity
have disclosed relevant financial interests or relationships of their own, their
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Content Review
The content of this manuscript has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias.
Author Disclosure(s)
Florence Lefranc, M.D., Ph.D.
Credentials: Department of Neurosurgery, Erasme University
Hospital, Brussels, Belgium; Laboratory of Toxicology, Institute of Pharmacy,
Université Libre de Bruxelles, Brussels, Belgium.
Disclosures: The author has indicated no relevant commercial
relationships.
Vincenzo Facchini, Ph.D.
Credentials: Unibioscreen SA, Brussels, Belgium.
Disclosures: The author has indicated no relevant commercial
relationships.
Robert Kiss, Ph.D.
Credentials: Laboratory of Toxicology, Institute of Pharmacy,
Université Libre de Bruxelles, Brussels, Belgium. Telephone:
32-474-477-192; Fax: 32-2-332-5335; E-mail: fllefran{at}ulb.ac.be.
Disclosures: The author has indicated no relevant commercial
relationships.
Section Editors Disclosures
Dwight Kaufman, M.D., Ph.D., and Jayne Gurtler, M.D., F.A.C.P., have disclosed no financial relationships relevant to the content of this article.
CME Activity Director Disclosure
Frank M. Balis, M.D., CME Activity Director, Clinical Director, National Cancer Institute, has disclosed no financial relationships relevant to the content of this article.
Independent Peer Reviewers and Staff Managers Disclosures
No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers or staff managers.
Commercial Support
Non-governmental supporters of this activity: Abraxis BioScience,
AstraZeneca, Bristol-Myers Squibb Oncology, Merck, Pfizer, and sanofi-aventis
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