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Glucarpidase (Carboxypeptidase G2) Intervention in Adult and Elderly Cancer Patients with Renal Dysfunction and Delayed Methotrexate Elimination After High-Dose Methotrexate Therapy

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CME Activity Information
Release Date: November 30, 2007
Most Recent Review: November 30, 2007*
Most Recent Update: November 30, 2007
Date Credit Expires: November 30, 2009
Time to Complete: 1 hour
Medium: Internet Online
*Click here to learn more about our review process.
Instructions for Participation

  1. Read the following information before beginning the educational activity and click the "Take this course" link at the bottom of the page
  2. Study the educational activity
  3. Complete the CME quiz and evaluation
  4. After successful completion of the CME quiz and evaluation, you will receive the credit or participation certificate

    *The CME quiz and evaluation must be completed by November 30, 2009, in order to receive the credit or participation certificate.

 

Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine in clincial pharmacology and are involved in providing patient care in a cancer care environment.

Learning Objectives
After completing this course, the reader should be able to:
  1. Identify risk factors for kidney failure associated with high-dose MTX therapy.
  2. Discuss the therapeutic options in patients with delayed MTX elimination.
  3. Discuss the potential risks and benefits of glucarpidase intervention.
Accreditation and Credit Designation
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the School of Medicine of The University of North Carolina at Chapel Hill and The Oncologist. The School of Medicine of The University of North Carolina at Chapel Hill is accredited by the ACCME to provide continuing medical education for physicians.

The School of Medicine of The University of North Carolina at Chapel Hill designates this educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Policy
In compliance with the Standards of the ACCME, it is the policy of the School of Medicine of The University of North Carolina at Chapel Hill to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities and to include information free of commercial bias and based on the best evidence available. All individuals in a position to influence the content of this activity have disclosed relevant financial interests or relationships of their own, their spouse/partner, or their worksite, with manufacturers or providers of commercial products, services, technology, or programs; and disclosed relationships with current non-governmental supporters of the activity.

All information is submitted and reviewed and found to be scientifically rigorous, based on the best available evidence, fair and balanced, and free of commercial bias. All the recommendations involving clinical medicine in this CME activity are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection and analysis.

Any potential conflicts of interests are resolved via The Oncologist's anonymous peer review process All manuscripts are reviewed by the Editorial Board with ad hoc assistance from two or more external experts in the field. All final publication decisions are made by the Editorial Board. The acceptance of a manuscript is based on its originality and importance to the field as assessed by the Editors.

Content Review
The content of this manuscript has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias.

Author Disclosure(s)
Stefan Schwartz, M.D.

Credentials: Medizinische Klinik III, Charité, Campus Benjamin Franklin, Berlin, Germany. Telephone: 49-30-8445-2337; Fax: 49-30-8445-4468; E-mail: stefan.schwartz{at}charite.de.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author also has acted as a consultant to and has received financial research support from Protherics PLC.

Klaus Borner, M.D.

Credentials: Institut für Klinische Chemie und Pathobiochemie, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author has indicated no relevant commercial relationships.

Krystina Müller, M.D.

Credentials: Medizinische Klinik III, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author has indicated no relevant commercial relationships.

Peter Martus, M.D.

Credentials: Institut für Biometrie und Klinische Epidemiologie, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated no relevant commercial relationships.

Lars Fischer, M.D.

Credentials: Medizinische Klinik III, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author has indicated no relevant commercial relationships.

Agnieszka Korfel, M.D.

Credentials: Medizinische Klinik III, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author has indicated no relevant commercial relationships.

Timothy Auton, M.D.

Credentials: Protherics PLC, Runcorn, United Kingdom.
Disclosures: The author has indicated that they discuss the unlabeled, investigational, or alternative use(s) of glucarpidase, manufactured by Protherics PLC, as a methotrexate antidote. The author also has a financial interest in Protherics PLC.

Eckhard Thiel, M.D.

Credentials: Medizinische Klinik III, Charité, Campus Benjamin Franklin, Berlin, Germany.
Disclosures: The author has indicated no relevant commercial relationships.

Section Editor Disclosure
Jan H. M. Schellens, M.D., Ph.D., has disclosed no financial relationships relevant to the content of this article.

CME Activity Director Disclosure
Frank M. Balis, M.D., CME Activity Director, Clinical Director, National Cancer Institute, has disclosed no financial relationships relevant to the content of this article.

Independent Peer Reviewers and Staff Managers Disclosures
No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers or staff managers.

Commercial Support
Non-governmental supporters of this activity: Abraxis BioScience, AstraZeneca, Bristol-Myers Squibb Oncology, Merck, Pfizer, and sanofi-aventis

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