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Response to Treatment and Survival of Patients with Non-Small Cell Lung Cancer Undergoing Somatic EGFR Mutation Testing

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CME Activity Information
Release Date: January 16, 2007
Most Recent Review: January 16, 2007*
Most Recent Update: January 16, 2007
Date Credit Expires: January 16, 2009
Time to Complete: 1 hour
Medium: Internet Online
*Click here to learn more about our review process.
Instructions for Participation

  1. Read the following information before beginning the educational activity and click the "Take this course" link at the bottom of the page
  2. Study the educational activity
  3. Complete the CME quiz and evaluation
  4. After successful completion of the CME quiz and evaluation, you will receive the credit or participation certificate

    *The CME quiz and evaluation must be completed by January 16, 2009, in order to receive the credit or participation certificate.

 

Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine in lung cancer and are involved in providing patient care in a cancer care environment.

Learning Objectives
After completing this course, the reader should be able to:
  1. Identify clinical factors that predict for the presence of a somatic EGFR mutation.
  2. Discuss clinical outcomes that may differ depending on EGFR mutation status.
  3. Describe the more common types of EGFR mutations that have defined clinical implications, as compared to the rare EGFR mutations of which the significance is not yet known.
Accreditation and Credit Designation
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the National Institutes of Health Foundation for Advance Education in the Sciences (NIH/FAES) and The Oncologist. The NIH/FAES is accredited by the ACCME to provide continuing medical education for physicians.

The NIH/FAES designates this educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Policy
In compliance with the Standards of the ACCME, it is the policy of the NIH/FAES to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities and to include information free of commercial bias and based on the best evidence available. All individuals in a position to influence the content of this activity have disclosed relevant financial interests or relationships of their own, their spouse/partner, or their worksite, with manufacturers or providers of commercial products, services, technology, or programs; and disclosed relationships with current non-governmental supporters of the activity. The faculty and planners have indicated that they have no relevant commercial relationships. For a list of the faculty and planners, please visit the Editorial Board online at http://cme.theoncologist.com/misc/edboard.shtml.

All information is submitted and reviewed and found to be scientifically rigorous, based on the best available evidence, fair and balanced, and free of commercial bias. All the recommendations involving clinical medicine in this CME activity are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection and analysis.

Any potential conflicts of interests are resolved via The Oncologist's anonymous peer review process: http://theoncologist.alphamedpress.org/misc/ifora.shtml. All manuscripts are reviewed by the Editorial Board with ad hoc assistance from two or more external experts in the field. All final publication decisions are made by the Editorial Board. The acceptance of a manuscript is based on its originality and importance to the field as assessed by the Editors.

Author Disclosure(s)
Lecia V. Sequist, M.D., M.P.H.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Telephone: 617-724-4000; Fax: 617-726-0453; E-mail: lvsequist{at}partners.org.
Disclosures: The author has indicated no relevant commercial relationships.

Victoria Joshi, Ph.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Pasi A. Jänne, M.D., Ph.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has received financial support from AstraZeneca and has intellectual property with Genzyme.

Alona Muzikansky, M.A.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Panos Fidias, M.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Matthew L. Meyerson, M.D., Ph.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has received Tarceva research support from Genentech.

Daniel A. Haber, M.D., Ph.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Raju Kucherlapati, Ph.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Bruce E. Johnson, M.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has served as a consultant and has received patent royalities for EGFR testing from Genzyme.

Thomas J. Lynch, M.D.

Credentials: Massachusetts General Hospital Cancer Center, Harvard Medical School/Partners HealthCare Center for Genetics and Genomics, Massachusetts General Hospital Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Disclosures: The author has served on the Board of Scientific Advisors for Imclone, sanofi-aventis, and Boerhinger-Ingelheim. The author has served as a consultant for Genentech, OSI Pharmaceuticals, Millenium Pharmaceuticals, and Telik. The author has received financial support from sanofi-aventis, Eli Lilly, AstraZeneca, Genentech, OSI Pharmaceuticals, and Genzyme.

Commercial Support
Non-governmental supporters of this activity: AstraZeneca, Bristol-Myers Squibb Oncology, and sanofi-aventis

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